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When compared to the placebo group, PBMCs isolated from individuals with T2DM who received L-GSH supplementation for 3-months had a significantly reduced burden of BCG ( Figure 6A )

Notably, given that SGLT-2 is expressed in the brain, which is consistent located with enhanced cFos expression induced by SGLT-2is, we hypothesize that SGLT-2is may cross the BBB via receptor-mediated transcytosis