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At steady state (around 4-5 weeks of weekly dosing), plasma concentrations stabilize, allowing for predictable glucose control and satiety signaling

This vascular stress can, in turn, contribute to heart rhythm disturbances and other problems

OOAC models have been employed to study various vascular diseases such as atherosclerosis, thrombosis, pulmonary arterial hypertension, and others as extensively reviewed by Amid Shakeri et al

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