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The global increase in the prevalence of CKD is linked to the increasing prevalence of traditional risk factors, including obesity, hypertension, and diabetes mellitus, as well as metabolic factors, particularly insulin resistance, dyslipidemia, and hyperuricemia

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Such accumulation also promotes cell wall metabolism and cross-linking through oxidative processes

N Engl J Med 323 : 16 Taaffe DR et al

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