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A better understanding of these adaptive mechanisms of gastric mucosa after RYGB and VSG and their exploitation will help in the development of new approaches to bariatric surgeries and possibly allow to replace them with less invasive and gastric-targeted endocrine therapies for the treatment of obesity-related diabetes

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doi: 10.1038/s41591-024-02996-7

When we eat food, our digestive system breaks down complex carbohydrates into simple sugars which then go into the bloodstream leading to elevated blood sugar levels

We also recently discovered that HFD impairs intestinal NAMPT-mediated NAD + biosynthesis and disrupts the Wnt signaling pathway, GLP-1 production, and whole-body glucose metabolism