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This mechanism is primarily associated with inhibiting Mincle and its associated signaling components Syk and NF-B, which regulate macrophage polarizationspecifically reducing pro-inflammatory M1 phenotypes while enhancing anti-inflammatory M2 populations
Clin Trans Immunol
Nat Rev Microbiol 16(3):156170 Hallett RL et al (2004) Combination therapy counteracts the enhanced transmission of drug-resistant malaria parasites to mosquitoes
