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A randomized, double-blind, placebo-controlled, crossover study evaluated bone markers of formation and resorption in 17 overweight or obese men without T2DM who received sequence infusions of GIP alone, GLP-1 alone, a combination of GIP and GLP-1, and placebo [72]

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Depending on the clinical picture, that typically includes: Relevant baseline bloodwork before starting IGF-1 dynamics where appropriate, so the response can be tracked rather than assumed Glucose and metabolic markers where relevant Follow-up adjustments based on results, tolerability, and goals A clear plan for duration and review rather than indefinite open-ended use This is also why CJC-1295 and Ipamorelin are often discussed alongside related options like Tesamorelin for visceral fat and metabolic goals

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JNCI: J Natl Cancer Institute