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However, the role of Rab4A-mediated endosome traffic beyond mTOR activation, T-cell lineage development and autoimmunity remain unknown

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They are support, not enhancement

10.1016/j.tox.2005.08.003 Toxicology 72 VredenburgG.EliasN

Persistent side effects beyond 2 weeks after a dose increase Transient nausea, mild constipation, and decreased appetite are expected and normal during the 1 to 2 weeks after each dose increase

The concentration is higher than intended