Never freeze a reconstituted solution
ClpB has been reported to suppress appetite 14,35
In Phase 3 clinical trials, retatrutide has been studied as a once-weekly injection, starting at 2mg once weekly and increasing gradually every four weeks
Alternative medication classes should be considered if GLP-1 therapy proves intolerable: SGLT2 inhibitors (such as dapagliflozin, empagliflozin) for type 2 diabetes, which work via a completely different mechanism and rarely cause gastrointestinal side effects DPP-4 inhibitors (such as sitagliptin, linagliptin), which enhance endogenous GLP-1 activity more gently Metformin remains first-line for type 2 diabetes, though it can also cause gastrointestinal side effects Orlistat for weight management, though this also has gastrointestinal side effects of a different nature For weight management specifically, NICE recommends a comprehensive approach including dietary modification, increased physical activity, and behavioural interventions, with or without pharmacotherapy
Side effects such as nausea, GI upset, and transient fatigue are commonly reported and may require dose adjustments
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