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Additionally, ketogenic diets, in theory, can also have a similar impact to calorie restriction, by downregulation of IGF-1 and insulin, promoting PI3K inhibition function, and through increased exposure to oxidative stress for the tumour cells [148,149,150]
Arese P, De Fiora A
It then further converts to -ketoglutarate (-KG) through the action of glutamate dehydrogenase (GLUD) or transaminases, entering the tricarboxylic acid (TCA) cycle, generating reduced nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FADH2), and ultimately producing adenosine triphosphate (ATP)
View Source Life sciences Alcohol-induced oxidative stress 2007 DOI: 10.1016/j.lfs.2007.05.005 PMID: 17570440 Das SK, Vasudevan DM View Source Pathology, research and practice Short term deuterium depletion in drinking water reduced tumor induced oxidative stress in mice liver 2022 DOI: 10.1016/j.prp.2022.154186 PMID: 36327814 Bayrak BB, Kulak GY, Yanardag R, et al
The careful answer is that they may support collagen, elastin, repair signaling, and inflammation control, but topical anti-aging trials are much thinner than the marketing often implies [1][2]
