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84,85,86 Most cancer cells overexpress IDO, and the level of kynurenine in the microenvironment is associated with poor prognosis in multiple solid and hematological malignancies

IF enhances metabolic flexibility and energy efficiency by promoting fatty acid oxidation and inhibiting its synthesis through the activation of AMPK and SIRT1 signaling pathways (73)

Although the overall disease progression of NAFLD has been characterized, the exact mechanism(s) underlying its initiation and progression remain poorly defined

However, the reduction in pre-B cells during zinc deficiency mirrors the effect observed in T cells and is associated with altered glucocorticoid metabolism and increased apoptosis, highlighting shared mechanisms of immune impairment under zinc deficiency [376]

This evidence gap is the single largest limitation of peptide-based approaches

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