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N Engl J Med 326: 13161322, 1992
Starting with a murine ileum explant model, the authors showed that intraluminal LPS could stimulate GLP-1 secretion and that GLP-1 secretion was rapidly increased after direct LPS stimulation of an EEC cell line (STC-1 cells)
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Some of the most common GLP-1 medications many people are being prescribed for weight loss include: Semaglutide: Wegovy (FDA-approved for weight loss), Ozempic (prescribed off-label) Liraglutide: Saxenda (FDA-approved for weight loss), Victoza (prescribed off-label) Tirzepatide: Mounjaro (prescribed off-label), which is a dual GLP and GIP agonist, meaning it mimics the action of both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP), a hormone produced in the gut also involved in regulating blood sugar Interestingly, Saini says, GLP-1s also appear to have other health benefits researchers are still learning about
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