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Mitophagy is typically induced by compromising mitochondrial integrity, often through the use of OXPHOS inhibitors

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HR = 0.90 (125)], even in those patients with previous heart failure (132134), suggesting that the increased risk with saxagliptin is not mechanistically related to the inhibition of DPP-4 per se , but the cause is still unexplained

This includes: The S0 category prohibits any pharmacological substance with no current approval by any governmental regulatory health authority for human therapeutic use