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Requirements of vitamin B 12 in excess of normal (due to pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be met with intranasal or oral supplementation

PEM is a debilitating aspect of all three conditions, leading patients to pace their activities to avoid triggering these symptoms (Stussman et al., 2023

Every patient begins with a professional consultation to ensure suitability and to assess their specific symptoms and medical history

Key Modification

Gold and colleagues developed SOMAmer, a method that mimics protein side chains by attaching amide groups to deoxyuridine triphosphate at the 5 position aggrandizing the diversity of nucleic acids (128)

Donahue SP, Phillips LS