During the study, one patient died and another was hospitalized, but these events were not considered related to study participation
Current studies mainly focus on combinations with dietary control, exercise, and other weightloss agents, aiming to enhance efficacy and reduce side effects
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Other herbivores obtain low levels of B12 in their diets through soil and faeces, which also contain B12-producing microorganisms
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Suppression of gastric acid secretion by omeprazole reduces intestinal absorption of zinc.[232] This study indicates that intragastric pH and salt solubility-dissolution are important in the oral absorption of zinc.[233] Further, in vitro studies have confirmed the dependency of folate absorption on intraluminal pH.[235] In one study, when folate was given to achlorhydric patients (with no stomach acid) along with an HCl supplement, absorption of folate increased by 54%.[235] Although there is currently no available research on PPI risk of malabsorption of other nutrients, given that gastrointestinal pH plays an important role in absorption of various vitamins and minerals, one has to consider the probability that the absorption of other nutrients are affected as well
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