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A study shows that RIP3 (receptor-interacting protein kinase 3)-mediated necroptosis in retinal microglia triggers the release of pro-inflammatory cytokines such as TNF- and IL-6, promoting neuroinflammation and early neurodegeneration in diabetic retinopathy (DR) models, with genetic RIP3 knockout significantly reducing microglial activation, cytokine production, and retinal homeostasis disruption (52)
Vocal fold nodules most commonly develop from chronic vocal fold misuse