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Consistent with the knockdown results, BAY-876 or SU056 dampened cell proliferation without significant cell death, whereas dramatic cell death was observed in the combination treatment group (Fig

Together, these studies argue that FSP1 can represent (1) a context-dependent essentiality (for example, metastatic niches) and/or (2) a stand-alone oxidative defense node that becomes rate limiting for tumor survival under physiological stressors encountered in vivo