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In GLP-1R and GCGR, ECL1 forms a short -helix structure adjacent to the extracellular tips of TM2 in GLP-1R and TM3 in GCGR (Fig

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Double Incretin Receptor Knockout (DIRKO) Mice Reveal an Essential Role for the Enteroinsular Axis in Transducing the Glucoregulatory Actions of DPP-IV Inhibitors