According to clinical trials published in the New England Journal of Medicine, Zepbound shows slightly higher rates of GI effects at higher doses: nausea (31-33%), diarrhea (21-23%), and vomiting (12-20%)
Tirzepatide (Mounjaro) a dual GLP-1/GIP agonist licensed in the UK for type 2 diabetes and, following a positive NICE technology appraisal (TA1026), recommended for weight management in eligible adults within specialist services
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1 Some have cited concern over confounding variables including the fact that patients with diabetes are at an increased risk of acute pancreatitis regardless of treatment choice
Always consult a doctor before starting any medicine
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