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In the landmark SURMOUNT-1 trial, participants receiving the highest dose of tirzepatide lost an average of 22.5% of their body weight over 72 weeks, making it one of the most effective pharmaceutical weight loss interventions available (Jastreboff et al., 2022, New England Journal of Medicine )

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The suggested dithiol mechanism for the reduction of EcRNR by EcGrx1 comprises a dithiol-disulfide exchange reaction followed by the stepwise reduction of EcGrx1(S 2 ) and EcGrx1(SSG) by two molecules of GSH (Fig

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