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Microdosing semaglutide, typically at doses of 0.1 to 0.5 mg per week, has gained attention for researchers who want milder appetite effects, metabolic benefits without dramatic weight loss, or a more conservative approach

Rotating injection sites regularly can prevent tissue irritation and ensure consistent medication absorption

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Joo E, Harada N, Yamane S et al (2017) Inhibition of gastric inhibitory polypeptide receptor signaling in adipose tissue reduces insulin resistance and hepatic steatosis in high-fat dietfed mice

They work by mimicking the GLP-1 hormone in the body that controls insulin and blood glucose levels, and their effects on the brain can reduce hunger, helping people feel full for longer