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The primary goals were to assess the percentage change in body weight and the accomplishment of a weight loss of 5% by week 104

After 52 weeks of follow-up, after the medication was withdrawn, the average weight loss was 5.6% with semaglutide and 0.1% with placebo

Nature 542 , 177185 (2017)

However, if you have a contraindication like medullary thyroid cancer history or pregnancy, semaglutide is medically inappropriate regardless of cost

8.1 Endpoint hierarchy and measurement standardisation Current studies show substantial heterogeneity in endpoint selection (97)

Early data shows a reduction in flare-ups (exacerbations) one of the biggest challenges in conditions like COPD