Davis JL, OConnor M, Erlbacher H, Schlichte SL, Stevens HE
But the benefits go far beyond the immune system
Try milk thistle: This herb is composed of three compounds collectively known as silymarin, which has been shown to increase glutathione levels and prevent depletion 13
We talk through every risk, benefit, and alternative before any treatment
20 min LH, due to hyperglycosylation) Mechanisms of Action: LH/hCG Receptor Activation (LHCGR): Receptor: GPCR (7-transmembrane) in testicular Leydig cells, ovarian theca Translation: Gs protein coupling adenylate cyclase cAMP PKA Cascade: StAR (steroidogenic acute regulatory protein) phosphorylation Result: Mitochondrial cholesterol transport steroidogenesis Testicular Steroidogenesis: Leydig cells: testosterone synthesis stimulation Key enzymes: CYP11A1 (side-chain cleavage), 3-HSD, 17-HSD Testosterone production: 200400% increase in baseline levels Paracrine effects: spermatogenesis support (Sertoli cells) Ovarian Function Preovulatory follicle: final maturation, ovulation Corpus luteum: maintenance of progesterone production Luteinization: granulosa/theca cell differentiation Angiogenesis: luteal body vascularization (VEGF pathway) Recombinant hCG Pharmacokinetics: SC bioavailability: 4050% (vs
& Zetterberg, H
