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These include mono agonists, glucagonlike peptide-1 receptor agonists (GLP-1 agonists), and dual agonists that combine a glucose-dependent insulinotropic polypeptide (GIP) with a GLP-1 agonist (GIP/GLP-1), which have demonstrated a 15% and greater weight loss in people with obesity and/or type 2 diabetes, says Richard E

"We believe retatrutide could become an important option for patients with significant weight loss needs and certain complications." Participants with obesity and knee arthritis who took a 12-mg dose of retatrutide saw an average weight loss of 71.8 lbs (28.7%) at 68 weeks

Figure 2: Semaglutide Side Effects Week by Week Timeline

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But this complex interplay of hormonal signals is precisely why we need to look closely at its effects on systems beyond metabolism, like the heart

Here, a further caveat is in order