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[Abstract] Male C57BL/6 mice are intragastrically treated with Metformin or placebo at 3 mg/kg/day for 10 weeks in the presence of HFD after 10-week-HFD feeding and then sacrificed for sample collection

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The headline finding: spironolactone was well tolerated

According to the Merck Manuals, bioavailability is the extent and rate within which an active drug enters systemic circulation after passing through the first-pass metabolism sites, namely, the intestinal wall and liver

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