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Pyruvate is the final product of glycolysis and the initial organic acid that enters the TCA cycle of respiration, while malate and succinate are key intermediates in the TCA cycle for the generation of reductants and adenosine triphosphate (ATP) (Akram 2014)
However, the global pervasiveness of SARS-CoV-2 along with the emergence of S protein variants could potentially limit vaccine efficacy
The interplay between calcium and iron metabolism is complex, as elevated intracellular calcium levels can further promote iron-induced cellular damage, creating a vicious cycle of injury in the myocardium ( Atrial and ventricular tachyarrhythmias can develop due to heterogeneous electrical conduction and repolarization ( 2+ currents, resulting in atrial fibrillation ( Oxidative stress In -thalassemia, ineffective erythropoiesis results in increased hemolysis and the release of free hemoglobin, which further exacerbates oxidative stress through the Fenton reaction, where iron catalyzes the conversion of hydrogen peroxide into highly reactive hydroxyl radicals ( Glutathione (GSH), a key antioxidant in the body, plays a vital role in mitigating oxidative stress
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Antioxidant action of vitamin E in vivo as assessed from its reaction products with multiple biological oxidants
