G6PD inhibition has been shown to impair cellular migration through ROS-dependent inhibition of protein phosphatases involved in cytoskeletal rearrangement, suggesting that chronic ROS accumulation in G6PD-d may inhibit B1 migration necessary for IgM OSE production 87,144,145 (Fig
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While physiological levels of ROS contribute to the induction and maintenance of hippocampal LTP, excessive accumulation may impair neurotransmission and cognitive processing
4) Balendiran GK1, Dabur R, Fraser D
Research for effective treatments for Alzheimers disease (AD) is ongoing, but drug development faces challenges with a high failure rate
Dis Esophagus 24(3):147-52, 2011