semaglutide to lose 15 pounds Two Years After Stopping GLP-1s, Most Patients Sustain at Least Some Weight Loss Semaglutide: Shedding pounds, weighing risks

BMJ 2020;371:m4147.ArticlePubMed 108

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Impaired mitophagy leads to the accumulation of dysfunctional mitochondria that leak ROS and pro-apoptotic factors like Cytochrome C

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Angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) binds at the AT 1 receptor subtype and mediates systemic blood pressure, body water/electrolyte balance and influences cerebral blood flow, cerebroprotection, seizure, stress and depression