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Culp-Hill, R

GLP-1R agonist 2 (100 nM, 1,000 nM) promotes glucose-dependent insulin secretion in CD1 mouse islets, and this effect is dependent on the GLP-1 receptor

S.HamdaouiM

David Henry - beneficios riesgos GLP1 David Henry Profesor honorario adjunto en la facultad de Ciencia y Medicina del Instituto para la Atencin de la Salud Basada en la Evidencia de la Universidad Bond, la Universidad de Nueva Gales del Sur y la Universidad de Melbourne (Australia) El artculo describe un enfoque basado en datos para estudiar posibles efectos beneficiosos y adversos de los agonistas del GLP-1, como la semaglutida (Ozempic), que se utilizan ampliamente para tratar la diabetes y la obesidad

Editing efficiency was determined on bulk-edited cell populations by targeted PCR of the Cas9-targeted region and secondary PCR using overhang sequences (Table S1), followed by Illumina MiSeq, as previously described (Aubrey et al, 2015)

GLP-1 receptor agonists intentionally slow gastric emptying to promote satiety and reduce blood glucose spikesbut this mechanism poses a significant safety concern for patients with existing gastroparesis