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Average: 13 to 16 percent body weight loss

While the drug appeared to show higher rates of certain gastrointestinal side effects, such as nausea and diarrhea, especially at the highest dose, they were generally consistent with a previous Phase 3 trial of retatrutide in patients with obesity and a type of knee arthritis pain

People who started with significant visceral fat see major reductions in waist circumference

Acheson KJ, Zahorska-Markiewicz B, Pittet P, Anantharaman K, Jquier E

Obesity as a Public Health Crisis and Contemporary Therapies Between 2021 and 2023, the prevalence of obesity, defined as a body-mass index (BMI, weight in kilograms divided by square of height in meters) 30, in adults in the United States increased to 40.3%, with no significant differences between men and women [6]