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A hangover is caused by an accumulation of toxins in the body that build up as a result of alcohol consumption

European Journal of Clinical Pharmacology, 43 (6), 667669

Observations are reported in study populations (usually animal or cell models), not guaranteed for any individual

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Data were processed with MestReNova (14.2.1) software

To further substantiate the requirement of hydrolysis for signalling complex formation, we generated two catalytically inactive HTL7 mutants: HTL7 S95C (a conservative substitution of the catalytic serine) and HTL7 D217A (a non-homologous substitution of the catalytic aspartate)