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The Asp9 forms a hydrogen bond with Arg370, while Ser8 and Ser11 of Tirzepatide form a network of hydrogen bonds involving the receptor residue Glu288, Arg 289, and Asn290

1 Smith, E., Ramirez, B., & Johnson, K

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Who GLP-1 is for Adults seeking medically supervised weight loss, typically with a higher BMI or a weight-related health concern, who clear the eligibility screen and have no contraindications (notably no personal or family history of medullary thyroid carcinoma or MEN 2, and not pregnant or breastfeeding)

Both may be used in medical weight management when appropriate, but they differ in mechanism, dosing, tolerance, expected response, and patient suitability