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This phenomenon is reminiscent of autoprotection observed in experimental animals, where initial exposure to the sub-toxic doses of acetaminophen protects rodents from subsequent lethal doses of the drug [59,60]

Total escalation period: 12 weeks from initiation to full maintenance dose

Due to the available data, there is no information on the exact BMI of the patients

doi: 10.1016/j.clinthera.2008.08.006 52 BuseJBHenryRRHanJKimDDFinemanMSBaronADet al

Drug-in-mucoadhesive type film for ocular anti-inflammatory potential of amlodipine: Effect of sulphobutyl-ether-beta-cyclodextrin on permeation and molecular docking characterization

Advances in the treatment of melasma: a review of the recent literature