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In this article: 1/ Common side effects of weight-loss medications 2/ Serious side effects of weight-loss medications 3/ What are the top FDA-approved medications for weight loss

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& Roubenoff, R

Bu T, Sun Z, Pan Y et al (2024) Glucagon-like peptide-1: new regulator in lipid metabolism

At 9mg weekly: Nausea: 38.1% Diarrhea: 34.7% Constipation: 21.8% Vomiting: approximately 15-20% At 12mg weekly: Nausea: 43.2% Diarrhea: 33.1% Constipation: 25.0% Vomiting: approximately 18-22% These numbers look concerning, but context matters

Glucagon-receptor activity is associated with increased energy expenditure and reduced liver fat, which is the mechanistic rationale for why retatrutide produced larger weight-loss figures in early trials