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JCI Insight 7 , e159863 (2022)

Clinical trials used doses as high as 1 mg per day without safety concerns, but 300 mcg is the most commonly referenced dose in peptide medicine literature and in the investigational protocols that have been published since the formal trials concluded

As this E3 has now been harnessed to degrade several targets, elucidation of the structural basis of complex formation is essential for optimizing existing FBXO22-recruiting degraders and for enabling the rational design of degraders for additional protein targets

IAV can induce glutathionylation, and glutaredoxin-1-mediated deglutathionylation exerts an inhibitory effect on viral replication 71

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