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In clinical trials, GI side effects were most common during dose escalation and were generally temporary and mild to moderate in severity (ref), though dedicated data on the duration of sleep-specific disruption is not yet available

It can also cause increased pain, bruising, bleeding, and the formation of hard lumps under the skin

What does retatrutide do and how does it work

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While the data are still preliminary, McCoy says, they indicate that retatrutide has greater efficacy over a placebo for blood sugar and weight loss compared with previous trials of tirzepatide (which targets two receptors) and semaglutide

Over-the-counter laxatives, anti-diarrhoeals, or antiemetics may be considered if dietary measures are insufficient, but should be discussed with a pharmacist or healthcare professional before use