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The problem is that plasma levels decline sharply with age: from approximately 200 ng/mL at age 20 to 80 ng/mL by age 60.9 That decline matters because GHK-Cu does something remarkable at the genetic level

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The biology behind it is not fully settled, but dose-response curves that peak and then fall off are common for signaling molecules, where too much of a stimulus can desensitize or overshoot the system it is meant to nudge