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Psychiatry 69, e113e125

Gut microbiome dysbiosis involved in IR Growing evidence in the last two decades has suggested that gut microbial dysbiosis contributes to increased risks of metabolic defects like obesity, IR, and diabetes

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Anthems standard PA criteria for weight-loss GLP-1s in 2026 require a BMI of 30 or higher, or a BMI of 27-29.9 with at least one weight-related comorbidity like hypertension, dyslipidemia, type 2 diabetes, or obstructive sleep apnea

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A similar drop in waist circumference were noted in SURPASS-4, and this reduction was sustained through 104 weeks [51, 53]