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An important conceptual implication of CoQ 10 biology is that, although CoQ 10 is synthesized in mitochondria, its protective function extends to multiple membrane compartments throughout the cell

Their functional plasticity, shifting between inflammatory, repair, or anti-inflammatory states, depends on metabolic adaptation and lipid remodeling, including choline uptake and phospholipid reorganization (66, 76)

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This switch is a process called methylation and it relies heavily on an enzyme called MTHFR (methylenetetrahydrofolate reductase)

Defense and repair are also impacted

Nakazono-Kusaba A, Takahashi-Yanaga F, Morimoto S, Furue M, Sasaguri T