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The effects of natural products on gut microbiota, metabolites, and molecular mechanisms in AKI and CKD Accumulating evidence demonstrates that natural products can ameliorate AKI by modulating gut microbiota ( Table 3 ) [96, 97]

Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice

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it is mainly due to malabsorptive syndromes (i.e., previous GI surgery, cholestatic liver disease with low bile concentration in the intestine) and clinically presents with altered immune function, retinopathy, peripheral neuropathy, ataxia, and hemolysis (78)

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Gargiulo AR, Hornstein MD