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According to the MHRA/EMC SmPC, these include nausea (occurring in approximately 44% of patients in clinical trials), vomiting, diarrhoea, constipation, and abdominal discomfort

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Due to (temporarily) reduced sodium reuptake while continuously promoting glucosuria, these drugs induce a reduction in GFR likely via activation of tubuloglomerular feedback (TGF) that may represent reduced intraglomerular pressure [5]