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Indeed, in models such as breast cancer, EPA/DHA treatment reduces the phosphorylation levels of kinases such as Akt and ERK, and inhibits the PI3K/Akt signaling pathway, which reduces pro-survival signaling and promotes apoptosis (60)

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[7] [8] [2] The deficiency may occur in pernicious anemia, following surgical removal of the stomach, with fish tapeworm, or due to bowel cancer