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Separately, a review of five randomised controlled trials presented at ENDO 2026 examined the effects of GLP-1 drugs such as semaglutide and liraglutide on male reproductive health

However, these agents are associated with increased thyroid cancer risk, and the packaging for these medications in the United States has a boxed warning stating that they are contraindicated in people with a personal or family history of medullary thyroid cancer and in patients with a diagnosis of multiple endocrine neoplasia syndrome type 2

With increasing cAMP levels, protein kinase A (PKA) and the exchange protein directly activated by cAMP-2 (Epac-2) are also activated

Simeon Gutman: Yeah, so the larger debate is a little bit of sales cannibalization and a potential bit of retail media cannibalization

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They may start thinking about food all day again, snacking more often, or losing the ability to stop when full