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Depleting GSH levels can exert detrimental effects on cancer cells, potentially augmenting the efficacy of chemotherapy and ionizing radiation treatments [211]

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these factors make GLP-1 RAs an alternative initial treatment option, with or without metformin based on glycemic needs, in T2DM patients with indicators of high-risk or established heart failure (HF) or CKD who cannot tolerate an SGLT2 inhibitor

Session 5 Deep Cellular Protection

De Craene, B

Viral protein, nsp14 , interacts with the catalytic domain of Sirt1, dysregulates Nrf2/HO1 axis, and impairs host antioxidant defense 53