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Protease-resistant IGFBPs could be a potential therapeutic agent in cancer therapy by preventing the mitogenic activity of IGF

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Extracted data included title, trial name, the first author, publication year, country/region, dose, administration route, median follow-up time, sample size, age, sex, race, body mass index (BMI), smoke, blood pressure, glycated hemoglobin (HbA1c), T2DM duration, estimated glomerular filtration rate (eGFR), baseline CVD or CKD, and measures of effect assessed by the hazard ratio (HR) and its 95% confidence interval (CI) for each of the cardiovascular outcomes