Insulin resistance is associated with an increase in the levels of TNF-, IL-6, and C-reactive protein (CRP) resulting in low grade inflammation (Tangvarasittichai et al
The most common typically strongest in the first 48 weeks as the body adapts include: Nausea (most common, usually dose-dependent) Diarrhoea or constipation Fatigue , especially during dose escalations Mild headache Reflux and acid reflux Loss of appetite (this is the therapeutic effect, not a side effect, but it can be uncomfortable) Less common but more serious effects warranting immediate physician review include pancreatitis, gallbladder disease, and kidney issues, particularly in patients with pre-existing conditions
Numbers come from the SURMOUNT-1 trial and are population averages, not promises for any individual
The genetics of obesity: from discovery to biology
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Kang SW, Chae HZ, Seo MS, Kim K, Baines IC, Rhee SG