The S 1 PESs for each antimetabolite contain two energy minima, one being the metal-to-ligand charge transfer (MLCT) and another the ligand- eld (LF) state
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Isolated mitochondria from these cells showed a substantial reduction in NAD+ and NADH compared to controls
Summary Many animal foods are high in vitamin B12
Serious adverse effects have not been widely reported, but long-term safety data in humans is lacking
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