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The primary function of L-Carnitine is to transport long-chain fatty acids into the mitochondria, where they are oxidized and turned into energy

Early pharmacokinetic data shows drop formulations can achieve therapeutic blood levels if dosed properly, but head-to-head comparison trials are still emerging

But they can be (and often are) prescribed off-label for that purpose, which is why theyre included in the table below

Patient preference for non-invasive oral administration over injections enhances adherence and convenience

In a call with investors after the results were announced, Martin Lange, executive vice president of R&D, chief scientific officer and member of the Management Board for Novo Nordisk, explained that Zepbound performed unusually well on efficacy compared to what has typically been reported in most previous trials of a similar nature. In a phase 3 trial in adults with pre-diabetes and obesity, participants had an average weight reduction of 22.9% on the highest dose of tirzepatide, 2.1% less weight loss than was seen in the CagriSema comparator trial

32,33,35 The lack of accumulation of intermediary metabolites suggests that the defect is located in the initial step of methionine transformation regulated by SAM synthe-tase