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How GLP-1 works: GLP-1 is a hormone produced in the gut during digestion that may help to maintain a feeling of fullness and support metabolic health

doi: 10.1056/NEJMoa2302392

Although circadian rhythm disruptions have not been reported in ZSF1 Obese animals, Zucker diabetic fatty rats (the maternal background of the ZSF1 Obese rat) lack circadian oscillations in their intestines 75 , our data suggests that semaglutide may be functioning to help normalize or re-regulate the cellular clock in rats with HFpEF

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Thomson, S

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