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In children, hGH is officially authorized for therapy in the following indications: GHD Growth failure due to chronic renal insufficiency Noonan syndrome Prader-Willi syndrome Short bowel syndrome (SBS) Short stature homeobox (SHOX)-containing gene deficiency Small-for-gestational-age infants Turner syndrome In adults, hGH is also FDA-approved for therapy in: GHD SBS Muscle wasting due to AIDS Recombinant hGH therapy effectively increases serum growth hormone levels, addressing symptoms associated with GHD in both children and adults

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157 SIRT1-mediated deacetylation of PLINs enhances lipophagy, representing a key mechanism for alleviating hepatic steatosis

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