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Its mechanism targets appetite regulation and gastric motility rather than direct insulinotropic effects

For chronic weight management, the FDA-approved indications generally include adults with a BMI of 30 or greater, or BMI 27 or greater with at least one weight-related condition (type 2 diabetes, hypertension, dyslipidemia, obstructive sleep apnea, cardiovascular disease)

Nucleosomes are organized as a combination of DNA intertwined with nuclear proteins, called histones

doi: 10.1016/j.phrs.2019.104588 57 SaxtonRASabatiniDM

A significant reduction in appetite and food intake was also observed with tirzepatide compared to placebo in people with T2D [45]